The overall objective of the course is to provide knowledge of the main biochemical parameters used in clinical practice to support the diagnostic process of organ pathologies. At the end of the course, students will demonstrate knowledge of: the parameters analyzed by the complete blood count and standard urinalysis; the laboratory tests used in the routine diagnosis of hematological diseases; the main markers of liver and kidney function; the main indicators of lipid profile and glucose metabolism; and the markers of myocardial necrosis.

Propedeutic knowledges in biology, biochemistry and genetics.

Laboratory evaluation of hematopoiesis. Complete blood count, erythrocyte sedimentation rate (ESR), standard urinalysis, necrosis markers, liver function markers, and lipid profile.

I. Antonazzi. E. Gulletta. MEDICINA DI LABORATORIO. Logica & Patologia Clinica. Seconda edizione. Piccin

Hematopoiesis and its laboratory evaluation. The blood sample. Hemocromocytometer and Erythrocyte Sedimentation Rate. Diagnostic meaning of erythrocytes’ morphology in the peripheral blood. Leukocytes: -non neoplastic disorders, abnormalities in differential counts and functional alterations. - neoplastic disorders of leukocytes: baseline classification and major haematological findings. Notes on renal and hepatic function and evaluation of lipid profile Markers of necrosis and inflammation.

Frontal lesson

The power point presentations relating to the teaching units are available on the moodle@units and Microsoft Teams IT platforms Violetta Borelli, Ph.D. Dipartimento di Scienze della Vita Universita' di Trieste Via A. Valerio 28 - 34127 - Trieste Tel: +39-040-5584033 email: borelliv@units.it Office hours: upon appointment

For this module it is a written test with multiple choice questions: 20 questions with 4 choice options to be carried out in 25 minutes. One point for each correct question, no penalty). Evaluation expressed in thirtieths. The evaluation will be divide in the following levels: -Excellent (30 -30 cum laude): excellent knowledge of the topic, excellent language use, and analytical and applicative capacity of the knowledge to real conditions. -Very good (27 -29): very good knowledge of the topic, very good language use, and analytical and applicative capacity of the knowledge to real conditions -Good (24-26): good knowledge of the topic, good language use, and appropriate analytical and applicative capacity of the knowledge to real conditions -Satisfactory (21-23): Although knowing the fundamentals of the discipline, the Student does not show a total mastery of the topics. However the Students a satisfactory language use and application of the knowledge to real situations. -Sufficient (18-20): Slightest knowledge of the main topics e technical language, limited analytical and applicative capacity of theorethical knowledge to real situations. -Not sufficient: The Students does not possess an accettable knowledge on several topics of the teaching programme.uation expressed in thirtieths

This teaching contributes to the realization of the UN objectives of the 2030 Agenda for Sustainable Development