Knowledge and Understanding The student must demonstrate mastery of knowledge related to the principles of pharmacokinetics and pharmacodynamics, with particular focus on the pharmacology of the main drugs of odontostomatological interest. Ability to Apply Knowledge The student must demonstrate acquired competencies and an understanding of the mechanism of action of drugs and their effects on the human body. Independent Judgment The student must demonstrate the ability to apply acquired knowledge with independent judgment. They should be able to identify the drugs of choice based on their pharmacokinetic and pharmacodynamic characteristics, with particular attention to drugs of odontostomatological interest. Communication Skills By the end of the course, the student must be able to clearly present the acquired concepts. Learning Ability The student must be able to independently deepen their understanding of the topics covered in the course through the consultation of scientific journals and specialized texts.

It is necessary for the student to have preliminary knowledge of anatomy, physiology, and microbiology.

Introduction to Pharmacology. Routes of drug administration.Pharmacokinetics: general aspects. Pharmacodynamics: general aspects .Variability in drug response .Drug interactions .Adverse drug reactions. Antimicrobial therapy: general principles of antibiotic therapy, main classes of antibiotics and antifungals. Anti-inflammatory and immunosuppressive drugs. Analgesic drugs. Antiplatelet and anticoagulant drugs. Anxiolytic drugs

Katzung & Trevor’s Pharmacology. Compendium and Multiple-Choice Questions, Piccin Publisher

General principles Route of administration Drug absorption, Bioavailability and Bioequivalence Drug distribution and barriers Biotransformation of drugs, Phase I and phase II reactions Excretion of drugs, Renal and biliary excretion Inter-individual variability and drug-drug interactions Drug adverse effects Mechanisms of drug action Drug Receptors Dose-response curves Agonists, partial agonists, antagonists, inverse agonists. Antimicrobial Agents General principles of antibiotic therapy β-lattam antibiotics, macrolides, metronidazole Antifungal agents Drug therapy of inflammation Non steroidal antiinflammatory drugs (NSAID) Glucocorticoids Antiaggregants and anticoagulants Antiplatelet drugs Oral anticoagulants (warfarin and NOAC) Heparin Local anesthetics Anxiolytics hypnotic, benzodiazepines

Lectures supported by slide projections.

PowerPoint slides used during the lectures will be provided to students. The professor is available for further clarifications and explanations upon contact via email. Any changes to what is here described will be communicated on the Department or Course website or directly to students during lectures.

An oral exam is scheduled. Through questions related to the contents, it will be determined whether the student has attained the required level of knowledge and understanding of the 133-ME2 teaching activity. To pass the exam (18/30), the student must demonstrate a basic knowledge of the required topics by adequately answering at least two questions. To achieve the highest score (30/30 with honors), the student must demonstrate an excellent understanding of all the required topics, expressing them with appropriate language proficiency. The grade for the partial exam (133-ME2 teaching activity) will be recorded in the designated section on the ESSE3 platform.

This course explores topics closely related to one or more objectives of the United Nations 2030 Agenda for Sustainable Development.