Knowledge and understanding: the student must acquire specific and targeted knowledge on general chemistry, such as the structure of the inorganic and organic matter, the laws that govern the chemical transformations and the structure and nature of the main classes of organic molecules with particular attention to those of biological interest. The course also aims to help the student to understand the main processes of the cellular metabolism. The module is oriented to the description of the structure and function of the main classes of biomolecules (proteins, nucleic acids, sugars and lipids), as well as the presentation of the complex interplay between the metabolic pathways (catabolic and biosynthetic)
Apply knowledge and understanding: the student must demonstrate skills to carry out chemistry exercises related to lecture topics. The student should be able to describe the interconnections between macromolecular structures and their function, the correlation that exists between the different metabolic pathways within a cell, organ or tissue, processes and mechanisms with which these metabolic pathways are regulated and how alterations of these processes can be related to pathological dysfunctions of a cell and an organism
Making judgements: the student must be able to critically discuss the different aspects of metabolic pathways and their correlation with pathological dysfunctions.
Communicative skills: ability to use a scientific lexicon .
Learning skills : the student must demonstrate to have faced the systematic study of chemistry and biochemistry autonomously and profitably and to be able to transfer the theoretical notions in real application situations

Mathematical capacity of simple numerical calculation for example solution of first and second degree equations and proportions.

Chemistry
The structure of matter and the atom, the periodic table of the elements, the types of chemical bonds
The states of matter
Chemical reactions
Solutions and their properties
Basics of chemical kinetics
Chemical equilibrium and its laws
Fundamentals of organic chemistr
Biochemistry
Major classes of biochemical molecules
Function of proteins: hemoglobin and myoglobin
Enzymes: catalysis and biological regulatory mechanisms
Glucidic and lipid metabolism. Amino acid catabolism. Bioenergetics. Hormonal regulation and integration of metabolism

Chimica e Biochimica per le laureee triennali e dell'area biomedica M.Samaja-R.Paroni Ed. Piccin Ed. Elsevier Teaching material provided by the teacher loaded on Teams platform: lessons slides, chemistry exercises, learning tests

Chemistry
The composition of matter: Heterogeneous and homogeneous systems, compounds and elements. Atom: elementary particles; atomic number, mass number, isotope, electronic structure of atoms.

Periodic table of elements: Periods and groups, periodic properties of elements, relationship between electronic structure and properties.

Chemical Bond: Strong chemical bonds, intermolecular bonds, polarity and electronegativity.

State of the matter

Inorganic chemistry: Nomenclature of chemical compounds

Chemical reactions and stoichiometry: Atomic and molecular weight, Avogadro's number, mole, conversion from moles to grams and vice versa, balancing chemical equations, examples of several chemical reactions

Solutions: Property of the water, solubility, how express the concentration of chemical solutions, colligative properties: osmosis and osmotic pressure.

Chemical Kinetics: Speed of chemical reactions and conditions that could influence it.

Chemical equilibrium: Law of mass action and equilibrium constant. Factors that influence the equilibrium. Le Chatelier's Principle

Equilibria in aqueous solution: Self-ionization of water, Kw. Definition of pH and pOH. Acid-Base Theories. Acids and bases in aqueous solution. Physiological buffer solutions and buffer systems.

Fundamentals of organic chemistry: Bonds between carbon atoms; raw formulas, structure, aliphatic, alicyclic and aromatic functional groups: alcohols, ethers, amines, aldehydes, ketones, carboxylic acids, esters, amides.

Biochemistry

Major classes of biochemical molecules: monosaccharides, disaccharides, polysaccharides, structure and functions; amino acids: classification, reactions; proteins structures, peptide bond; lipid structure and function.

Hemoglobin and myoglobin

Enzymes: catalysis and biological regulatory mechanisms

Carbohydrate metabolism: glycolysis, gluconeogenesis, pentose phosphate pathway, glycogen synthesis and the demolition and their regulation.

Fatty acid metabolism: oxidation of fatty acids, synthesis of ketone bodies, fatty acid
synthesis and their regulation

Amino acid catabolism: metabolic fate of amino groups, nitrogen excretion and urea cycle, amino acid degradation.

Bioenergetics: The citric acid cycle and its regulation, oxidative phosphorylation, electron flow and ATP synthesis.

Hormonal regulation and integration of metabolism

Lectures with the support of slides. At the end of the course, a few hours will be held to carry out chemistry exercises related to the topics discussed and which will provide an example of "type" exercises proposed during the exam.

The course slides will be uploaded to the Course's Teams platform. Attending and non-attending students may request also supplementary teaching material and information about the course and exam dates to the teacher by institutional email address (emarsich@units.it).

The written exam consisting of 3 open questions and 2 chemistry exercises. Duration of the test 2 hours. The assessments and the final mark are given as thirty points. Both the open questions and the numerical exercises are worth 6 points each. A score lower than 6 is also provided - from 5 points to 1 point if the answer is incomplete, only partially correct and the argument is presented in a convoluted manner with little or no knowledge of the language, 0 points if the student does not answer or does not demonstrate acceptable knowledge of the content The dates for the module examinations, the registration of the student for the partial examination and the notification of the grade to the student are managed on the ESSE3 platform

This course explores topics closely related to one or more goals of the United Nations 2030 Agenda for Sustainable Development (SDGs)