KNOWLEDGE AND UNDERSTANDING
- to know the cellular and molecular mechanisms controlling the innate and acquired immune responses;
- to know the etiopathogenetic mechanisms involved in major human diseases, with particular emphasis to pathologies related to cell injury, inflammation and neoplasia;
APPLYING KNOWLEDGE AND UNDERSTANDING
- to be able to pinpoint when and how the immune response intervenes to support the defense of the body towards injuries (infections, neoplasia)
- to be able to pinpoint, at both cellular and molecular level, the alterations of selected homeostatic mechanisms which underlie the onset and development of major human diseases, such as those related to cell stress, inflammatory reactions, and neoplasia.
MAKING JUDGEMENTS - Judgement autonomy will be developed while studying the matter to prepare the final examination. In this phase, the student will ascertain his ability to assimilate, elaborate and integrate the notions he learned during the lessons.
COMMUNICATION SKILLS - During the lessons, students' active partecipation will be stimulated. The use of appropriate scientific terms will be requested during this phase.
LEARNING SKILLS - Learning abilities will be developed as to allow the students to autonomously study the whole organization of the immune system as well as the aethiopathogenetic mechanisms of major human diseases. Learning skills well be ascertained by means of the indicated examination modalities.

Knowledge of fundamental topics in biochemistry, anatomy and phisiology will help the students in the comprehension of pathology issues.

INTRODUCTION TO PATHOLOGY
ETIOLOGY: causes of diseases
PATHOGENESIS

IMMUNITY AND IMMUNOPATHOLOGY
Blood cells
Antigens and antibodies
Natural and aquired immune response
Immune response towards infectious agents
Immunopathology: hypersensitivity, immune deficiency, autoimmune diseases

CELLULAR PATHOLOGY
Mechanisms and types of cell injury
Reversible and irreversible injury
Examplers of cell injurious stimuli
Cell and tissue adaptation of growth and differentiation
Mechanisms of cell death: necrosis and apoptosis

INFLAMMATION
Angioflogosis
Istoflogosis
Sistemic effects of inflammation
Inflammatory mediators
Inflammation in tissue damage and repair

NEOPLASIA
Main features and nomenclature
Molecular basis
Epidemiology
Biology of tumor growth
Tumor progression
Invasion and metastasis
Host-tumor interactions

• G.M Pontieri: Elementi di patologia generale
PICCIN Editore
3rd edition, 2012

INTRODUCTION TO PATHOLOGY
ETIOLOGY: causes of diseases
PATHOGENESIS

IMMUNITY AND IMMUNOPATHOLOGY
Blood cells
Antigens and antibodies
Natural and aquired immune response
Immune response towards infectious agents
Immunopathology: hypersensitivity, immune deficiency, autoimmune diseases

CELLULAR PATHOLOGY
Mechanisms and types of cell injury
Reversible and irreversible injury
Examples of cell injurious stimuli
Cell and tissue adaptation of growth and differentiation
Mechanisms of cell death: necrosis and apoptosis

INFLAMMATION
Angioflogosis
Istoflogosis
Sistemic effects of inflammation
Inflammatory mediators
Inflammation in tissue damage and repair

NEOPLASIA
Main features and nomenclature
Molecular basis
Epidemiology
Biology of tumor growth
Tumor progression
Invasion and metastasis
Host-tumor interactions

Frontal lessons

The power point presentations relating to the teaching units are available on the moodle@units and Microsoft Teams IT platforms Violetta Borelli PhD, Department of Life Sciences University of Trieste Via Valerio 28, building R 34127 Trieste Italy email: borelliv@units.it Tel +39 040 5588640 Orario di Ricevimento/ Office hours: da Lunedi a Venerdi ore 15-19 / Mon-Fri 15-19 Previa appuntamento / Upon appointment

Written test with multiple choice questions: 31 questions with 4 choice options to be carried out in 40 minutes. One point for each correct question, no penalty). Evaluation expressed in thirtieths.

This teaching contributes to the realization of the UN objectives of the 2030 Agenda for Sustainable Development